Breakthrough Discovery: How KIF18A and CENP-E Motor Proteins Drive Chromosome Alignment in Mitosis

Researchers Reveal a Game-Changer in Cell Division

Scientists from The University of Osaka, working alongside experts at MIT, have unlocked a crucial secret about how our cells divide. Their recent study shines a light on the exact way chromosomes line up during mitosis—a process called chromosome congression. Two key motor proteins, KIF18A and CENP-E, are at the heart of this discovery. These proteins work together to perfectly orchestrate chromosome movement and alignment, ensuring our cells divide without a hitch.

Microscopic Image of Chromosome Congression During Mitosis

A Potential Knockout Punch Against Cancer

What makes this research even more exciting? When scientists blocked both KIF18A and CENP-E at the same time, only cancer cells were selectively wiped out. Healthy cells seemed to manage just fine. This opens up a hopeful new pathway for cancer treatment, where therapy could target these motor proteins and leave normal cells untouched. Imagine telling your DNA, “Take a hike, cancer!”—now, that’s a superpower worth having.

It’s not every day science uncovers a potential double-whammy to cancer cells, all while deepening our understanding of life’s tiny mechanics. Sometimes, the smallest motors really do drive the biggest changes.

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