UMass Chan Medical School researchers have made a breakthrough discovery about genetic mutations. Their research reveals that transcription factors—proteins that regulate gene function—compete with DNA repair mechanisms. This competition can lead to an increase in errors during DNA repair, ultimately resulting in more genetic mutations.
Transcription Factors vs. DNA Repair
Transcription factors play a key role in turning genes on or off. But, according to UMass Chan scientists, these proteins can disrupt the body’s natural DNA repair operations. When transcription factors bind to DNA, they sometimes block access for DNA repair enzymes. This interference means damaged DNA doesn’t always get fixed properly, leading to permanent genetic errors.
Implications for Medicine
Understanding how transcription factors interfere with DNA repair offers new insight into the origins of genetic diseases, including cancer. This research could pave the way for targeted therapies that minimize mutation rates and improve DNA repair efficiency.
Sources:
UMass Chan Medical School News
