White Mold Fungi’s Split Genome May Revolutionize Gene Editing

New research challenges the belief that every cell nucleus holds a full set of chromosomes. Scientists have discovered that white mold fungi distribute their genome across multiple nuclei, with some nuclei holding only half the genetic material. This surprising finding may have major implications for the future of genetic engineering and gene editing in fungi.

White mold fungi genome research image

Why Fungi Split Their Genome

Until now, biologists believed that each cell’s nucleus contained a complete set of chromosomes. White mold fungi defy this rule by splitting their genome between different nuclei inside the same cell. This unique adaptation could help them survive environmental stress or outmaneuver plant defenses. It also means that gene editing methods, which typically target one set of DNA, might need to be rethought for these organisms.

Implications for Gene Editing

This discovery opens new doors for gene editing technologies in fungi. Scientists may need to develop new techniques for editing genes in organisms where the genetic blueprint is scattered among several nuclei. This could enhance our ability to control plant diseases caused by white mold fungi, potentially leading to healthier crops worldwide.

Sources:
Original article on The Conversation